Tag: senolytics

Aging discussion group meeting August 9, 2022: An overview the American Aging Association’s 50th annual meeting Part 3.

The meeting notice:

Hi all,

Wow, it is already time for another meeting.  I hope you are having as good a summer as I am.    Among other things I succeeded in selling one of my 6 plexes.  Since my goal is to sell one building per year, I am happy–and I even have someone interested in a second apartment building.

We will have our meeting at 11:30 on Tuesday the 9th.  Hope to finish by the time zoom cuts us off!  I have been thinking of alternatives like google meet or paying zoom the money for unlimited; anyone have any other suggestions?  Would any of you like to have the meetings in person, or perhaps a hybrid meeting (half in person, half over zoom)?

At this meeting I will attempt to finish the “brief” review of the American Aging Association’s 50th annual meeting.  If you find some topic that particularly interests you please let me know and I will expand on it in our October meeting.  Note that we hope to have a guest speaker at our September meeting.  As usual I will send the meeting link the morning of the meeting.

Summer is flying away…school starts soon and I am glad I am only taking one class (in addition to teaching another OLLI class…page 17, if you are interested).  I am hoping to have more time to invest in my blog as I finish off my summer projects…unfortunately I have a long way to go on them and may still be working on them in October!

Our July meeting is now on my DefeatingAging.com website.

I did not manage to read any interesting science articles this last month, but here are a few general articles I came across:

Of course our goal is to push toward increased health span.  Doing it is often a matter of changing our bad habits, which is very difficult.  For example my daughter made chocolate cake, which I ate in spite of the sugar spike I am sure I had from it!
I am closing in on hiring a Sri Lankan doctor.  It looks like I will not end up with a full doctor, but one who is an intern and will become a doctor soon(ie just out of med school).  If anyone is interested in reviewing some of the resumes/etc let me know.
It seems I messed up on last month’s emails.  I accidentally used an old list.  So I spent several hours this afternoon re-doing my email list completely to assure that it will not happen again.  To those of you that didn’t get the last meeting notice, my deepest apologies.  I hope you get a chance to watch the video on DefeatingAging.
One of my applicants to be our remote doctor wanted to write an article for us about a kind of medicine called Ayurveda which is practiced in Asia (India and neighboring countries).  It gives a completely different slant on many of the diseases of aging; whether the Ayurveda approach will be useful or not I am not sure.  Anyhow the article is done, hope to have it online by next month.  Anyone interested in helping edit let me know!
I am changing the blog posts that have our meeting videos.  From now on they will include these emails.  Any other improvements, please let me know.
I got a number of interesting emails from our members this last month.  I have been thinking of how to share them, but am not sure what format I should use.  Would you rather I put them on the blog or send them as an email (or both)?
Well this is plenty long.  As always, let me know if you don’t want to receive these any more.

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Link to the slides.

Forever Healthy Press Release, September 3, 2019

Forever Healthy is a German organization that has been supporting an annual aging conference in Berlin that I attend.  They are focused on expanding human health in old age.  Recently they sent me this press release and I found it so interesting I thought I would share it with you:

Forever Healthy launches Rejuvenation Therapies Evaluation Program with an in-depth analysis of NAD+ Restoration

Berlin, September 3, 2019

The Forever Healthy Foundation today announced the public launch of it’s “Rejuvenation Now” initiative and the publication of the first results of the project.

Senolytics, NAD+, Lipid Replacement, Decalcification, mTOR Inhibitors, Geroprotectors, … – the first generation of human rejuvenation therapies is available today. However, the field is still very young and the information often spotty. New therapies are emerging, and existing ones are updated or replaced. A real challenge for those who want to take advantage of this exciting development as soon as possible.

To overcome this, Forever Healthy’s “Rejuvenation Now” initiative seeks to continuously identify rejuvenation therapies that are available right now and systematically evaluates them on their risks, benefits, procedures and potential application in order to create transparency regarding the current state of said therapies.

The first publication released by the initiative is a “Risk & Benefit Analysis of NAD+ Restoration Therapy”, a systematic review of the published evidence. The team at Forever Healthy screened over 2000 publications resulting in the inclusion of more than 150 preclinical and 40 clinical trials on the use of oral NAD precursors, transdermal patches or infusions to raise NAD+ to youthful levels.

NAD+ Restoration Therapy: A Risk-Benefit Analysis

A second publication covering the intermittent use of high dose fisetin as a senolytic agent is already completed and under review by selected members of the rejuvenation community on the foundations RFC portal. It is expected to be released to the general public in the next weeks.

Future upcoming work of the initiative will amongst others cover topics such as the use of essential phospholipids to rejuvenate cell membranes and improve their condition, the use of low-level light therapy to rejuvenate the skin, and the use of EDTA to decalcify both arteries as well as the capillary system.

Rapamycin Doctor

While the cruise ship was in New York, I took the time to visit Dr. Green and get a prescription for rapamycin. While there I discussed with him other aging ‘cures’, which I outline in this blog.

As the cruise ship sailed from Iceland to Canada I started working on a blog about rapamycin. When I came across Dr. Alan Green’s website I got badly sidetracked, for Dr. Green has recently specialized in being a doctor of rapamycin. Partly because of the benefits he got from taking it himself. He is located in New York city and when I realized that I contacted him about an appointment for the day we docked there. With the short notice (5 days), and especially the fact it was a Sunday, I had my doubts it would work. My pessimism was misplaced, for he was kind enough to agree to meet with me at 2 pm.

Mostly I wanted to visit Dr. Green to see what he thought about rapamycin and to see what was required to get a prescription for it. Continue reading “Rapamycin Doctor”

In the beginning…

I am in my 60s and have been using aging research to slow my aging. This blog is about the science behind what I and others are doing to live a healthier lifestyle and hopefully live until science defeats aging.

I am already doing a number of things to (hopefully) slow my aging. I am in my 60’s and over the last decade I have had a few age-related health problems. I have successfully fought off these problems, such as my rheumatoid arthritis; a herniated disk in my neck, cured without surgery; my occasional brain fog is gone; a tremor in my hand is mostly gone; vision problems where I mostly reversed growing farsightedness from my eye lenses getting stiffer and failing to focus on things I read. As I get older, I expect that conquering these issues will become increasingly difficult and the biohacking techniques I have been using will start to fail me. So far my health remains excellent, and with the many treatments coming for slowing the onset of aging diseases I am hoping to extend my health into late old age–and perhaps until aging can be reversed.

Continue reading “In the beginning…”